Autoantibody Tests

2014-02-28 21:45

autoantibody tests1. What are Autoantibody Tests?

- ANA (Antinuclear Antibody), which is positive SLE (Systemic Lupus Erythematosus).

- Anti-dsDNA (anti-double stranded DNA), which is an important index to diagnose autoimmune disease that up to 80% of those with SLE or lupus nephritis will have a positive result.

- Anti-Smith. It is very specific for SLE and positive up to 30% of those with SLE.

- Anti-SS-A. It is positive in up to 75% of those with Sjögren's syndrome while up to 30~50% of those with SLE and scleroderma may also have positive result.

- Anti-SS-B. Positive in up to 60% of those with Sjögren's syndrome while up to 10~20% with those of SLE have the same result.

- Anti-RNP, which is positive in 95-100% of MCTD as well as those with SLE and Scleroderma for up to 30~50%.

- Anti-Jo-1. It may be positive with Polymyositis and Pulmonary Fibrosis.

- Scl-70. It may be positive in up to 60% of those with Scleroderma.

- GBM (Anti-Glomerular Basement Membrane). It is specific to diagnose various anti-GMB Glomerulonephritis, including pulmonary-renal syndrome.

- Anti-MPO. It is the main target antigen of p-ANCA, which is positive with necrotic or crescentic Glomerulonephritis.

- Protease 3, the main target antigen of c-ANCA, which is specific in diagnosing Wegener's granulomatosis.

- Anti-Ro-52, which is positive with myositis, scleroderma, rheumatic disease.

- Anti-M2 Antibody, which is particular in diagnosis of primary biliary cirrhosis.

- Anti-PM-ScI Antibody. It represents a specific marker for a subset of patients with scleroderma and polymyositis.

- Anti-ACA, which is associated with Progressive Focal Sclerosis.

- Anti-PCNA Antibody, which is a specific index to diagnose with SLE.

- Anti-histone Antibody. It is positive with SLE and RA.

- Anti-Rib-P Antibody. It indicates SLE and relates to lupus encephalopathy.

2. Why choose Autoantibody Tests?

Autoantibody tests is applied to find autoimmune disorder which implies the root cause of kidney diseases in most cases, thus helping your doctor to evaluate the severity of your condition, monitoring activity of immune disease and kidney damages as well as assessing the effectiveness of treatments.

In summary, autoantibody tests helps to figure out:

▪ whether your kidney damage is caused by autoimmune disorder;

▪ how serious your autoimmune disease is;

▪ specific drugs and cleaning method to deal with the excessive antibodies in your body.



What else you want to know:
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