IgA Nephropathy is a common renal disease affecting the health of adolescents in China, accounting for 30%-40% of the primary glomerulonephritis diagnosed by renal biopsy.
The immunopathological features of renal biopsy are granular deposition of IgA in the mesangial area of the glomerulus. Most of the patients are adolescents. The clinical manifestations are mainly naked eye hematuria, microscopic hematuria with or without proteinuria.
IgA nephropathy has a good prognosis. In the past 20 years, with the deepening of research, the understanding of IgA nephropathy has undergone profound changes. It has been found that many patients may have renal insufficiency after different stages of progress.
One of its important characteristics is that when serum creatinine rises to a certain extent, the disease progresses to end-stage renal disease in a short time, and various interventions can not reverse this process. Severe proteinuria, hypertension, renal interstitial fibrosis and tubular atrophy are important factors for poor prognosis.
IgA nephropathy is characterized by hematuria, which is often not accompanied by other clinical manifestations. Simple hematuria is often neglected by adolescents and families, so it is impossible to detect the disease early and make timely diagnosis and treatment.
Significant symptoms such as massive albuminuria, hypertension or edema, etc., have been reported to have a poor prognosis. This is also an important reason for the low renal long-term survival rate in patients with IgA nephropathy.
The general public should pay attention to regular urinary routine examination. Further examination should be carried out promptly after the discovery of hematuria by naked eyes or microscopy. Other diseases causing hematuria, such as renal tuberculosis, vascular malformations, urinary tract infections, thin basement membrane nephropathy, Nutcracker phenomenon, etc., should be excluded before the diagnosis of IgA nephropathy by renal puncture. State examination, kidney B ultrasonic examination, Doppler blood vessel ultrasonic examination and so on.
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